Deepa Sathyaseelan, Ph.D.
Education
Post Doctoral Fellowships, Kobe Pharmaceutical University (Japan) and University of Cambridge (UK)
PhD, University of Kerala, India
Research Overview
Research in my lab focuses on characterizing the role of inflammation in aging and age-related diseases. Age-associated increase in chronic, low-grade inflammation (inflammaging) is a hallmark of aging and age-associated diseases such as cancer, type 2 diabetes, Alzheimer’s disease etc. Our current studies aim to identify the molecular pathway(s) responsible for inflammaging and to determine if inflammation is a causative factor in aging and age-associated diseases.
Necroptosis (a form of programmed necrosis) is a novel cell death pathway that plays a major role in inflammation, however, little is known about the role of necroptosis in the age-related increase in chronic inflammation or aging. Using genetic and pharmacological approaches to block/reduce necroptosis in mice, we are studying the role of necroptosis-induced inflammation on lifespan and healthspan of mice.
Hepatocellular Carcinoma (HCC) is the sixth leading cause of mortality world wide and is predicted to be the top 3 causes of cancer mortality in the United Stated by 2030. Obesity and associated metabolic disorders are becoming a major risk factor for HCC in US in recent years. Using a mouse model that develops spontaneous HCC with age (mice deficient in CuZnSOD (Sod1-/- mice), we are studying the role of necroptosis-mediated inflammation in HCC development and progression.
Sathyaseelan Lab
Deepa Sathyaseelan, Ph.D.
Principal Investigator
Sabira M. Jazir, Ph.D.
Postdoctoral Fellow
Nidheesh Thadathil, Ph.D.
Postdoctoral Fellow
Evan Nicklas
Laboratory Assistant I
Contact
University of Oklahoma Health Science Center
975 NE 10th Street, BRC 1368B
Oklahoma City OK 73104
Phone: (405) 271-8001 ext.48393