​Deepa Sathyaseelan, Ph.D.


​Post Doctoral Fellowships, Kobe Pharmaceutical University (Japan) and University of Cambridge (UK)

PhD, ​​University of Kerala, India

​Research Overview

​Research in my lab focuses on characterizing the role of inflammation in aging and age-related diseases. Age-associated increase in chronic, low-grade inflammation (inflammaging) is a hallmark of aging and age-associated diseases such as cancer, type 2 diabetes, Alzheimer’s disease etc. Our current studies aim to identify the molecular pathway(s) responsible for inflammaging and to determine if inflammation is a causative factor in aging and age-associated diseases.
Necroptosis (a form of programmed necrosis) is a novel cell death pathway that plays a major role in inflammation, however, little is known about the role of necroptosis in the age-related increase in chronic inflammation or aging. Using genetic and pharmacological approaches to block/reduce necroptosis in mice, we are studying the role of necroptosis-induced inflammation on lifespan and healthspan of mice.
Hepatocellular Carcinoma (HCC) is the sixth leading cause of mortality world wide and is predicted to be the top 3 causes of cancer mortality in the United Stated by 2030. Obesity and associated metabolic disorders are becoming a major risk factor for HCC in US in recent years. Using a mouse model that develops spontaneous HCC with age (mice deficient in CuZnSOD (Sod1-/- mice), we are studying the role of necroptosis-mediated inflammation in HCC development and progression.

​Sathyaseelan Lab

Deepa Sathyaseelan, Ph.D.

Principal Investigator

Sabira M. Jazir, Ph.D.

Postdoctoral Fellow

​Nidheesh Thadathil, Ph.D.

Postdoctoral Fellow

​Evan Nicklas

​Laboratory Assistant I


​University of Oklahoma Health Science Center

​975 NE 10th Street, BRC 1368B

Oklahoma City OK 73104

​Phone: ​(405) 271-8001 ext.48393


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